Friday, August 29, 2014

Daily Newsletter: August 29, 2014 - Characteristics of Life

Daily Newsletter
August 29, 2014 

__________________________________________________

Characteristics of Life

In order to have a meaningful discussion about living systems, we must first identify that which we will consider "living."  To do this, we identify characteristics that will allow us to differentiate between living and non-living objects.  To be effective, these characteristics must be see in all examples of life.

As a first principle, we will start with the cell theory:  All living organisms are composed of cells, and all cells come from pre-existing cells.  Thus, the cell is the basic unit of life.  One of our goals this semester is to gain an understanding of the cell, and build a working model of how a cell functions.  As a frame four this semester long discussion, let's first look at how the characteristics of life are revealed in a cell.

  1. Homeostasis:  i.e., the same state.  This refers to the ability of a cell to maintain a constant 'internal' environment.  The environment around the cell can change (e.g., hot to cold, low salt to high salt), but the cell it self remains stable.  [Caveat:  All organisms have a range of environmental conditions where they can live; if you exceed the range, then the cell can not maintain homeostasis].  We shall see that the cell membrane is the defining structure of all cells, as it creates a boundary (inside vs. outside).  It is from this basic idea, and how we move things across the membrane, that we shall build the concept of homeostasis.
    • A corollary characteristic is adaptation.   Cells can change in response to the environment.  For example, bacterial cells can change the phospholipids in their cell membrane as temperature changes.  One way this is done is by changing the amount of saturated fatty acids used in making phospholipids.  
    • In order to adapt, you need to know how the environment changed.  This is done through systems of cellular receptors.  Stimulus (environmental change) ---> Receptor -----> Adaptation.  So cells also have the ability to Respond to Stimuli.  These stimuli could be physical factors (temperature or pH), or they could be chemical.  The thing to remember is that cells (and all life) have some type of Stimulus-Response (Receptor or Communication) system.
  2. Growth:  It is easy to see a human growing from infant, through adolescence, to adulthood.  But what about cells?  We could look for the growth in size, but that can be difficult when looking at a single cell.  Instead for cells, we look at Cell Number (population size) and/or Biomass (e.g., the amount of carbon or maybe the dry weight of the population).  Growth is based on two other characteristics of life.
    • Metabolism:  i.e.,  all chemical reactions in the body.  Often down played to just energy acquisition, metabolism also involves the acquisition of Carbon (needed for all biochemical compounds), other essential elements (like nitrogen), and the building of new biomolecules.  As cells make more biomolecules, they grow, and eventually divide.
    • Reproduction:  reproduction is essentially the creation of new individual organisms, and is easily seen when a baby is born.  But reproduction has its basis in cellular action.  A cell, when given the correct stimulus, can divide.  Possibly it has grown too large, or it may have received a chemical signal to divide.  In either case, a cell will divide into two daughter cells.  Terms that will come up with reproduction are: binary fision, mitosis, meiosis, and cytokineses.
  3. You may remember from other courses that Organization is often given as a characteristic.  Instead of talking about tissues and organs, I would remind you that living organisms are composed of cells.  If you have active, working cells, then you are living.  Doesn't matter if it is one cell or a million.

  

Wednesday, August 27, 2014

Daily Newsletter: August 27,2014 - Scientific Thought in Biology

BOLO Project Logo - www.bologsu.us/BOLO

Daily Newsletter

August 27,2014


Scientific Thought in Biology 

The goal today is to start to look at the questions: what is science? how do we do science?
Science is more than a collection of facts. Facts are important. We are constantly uncovering new facts.  But it is the analysis and incorporation of these facts into historic body of knowledge that makes up the foundation of science.  Science is dynamic, and we are ever increasing our knowledge base.
 Let's look at a slightly different question: What is the goal of science?

Take a moment and think about it. 
Why do people try to "figure" things out? 
Why do they "do" experiments?
One of my favorite phrases in answer to this question is that science provids us the power to predict and control natural phenomena. Such as predicting storms, identifying diseases, better crop management, and disease treatment to list just a few ways we predict and control natural phenomena.  Consider, we predict changes in the flu, and then control flu outbreaks through flu vaccination.

If you start looking into the Philosophy of Science you will find a number of different definitions, but for us, the above definition starts the discussion. 
 So how do we go about science?  Do we just propose an idea on how it works and leave it?  No!  We always want to TEST our ideas, and see if they provide a workable model. Our scientific method is based on the Hypetheticodeductive Model of Reasoning. Instead of naming the "steps" of the scientific method, I want you to instead break it down and really think about what it means.

First off, look at the word Hypetheticodeductive. It is constructed of two words: Hypothesis and Deductive. These are the two critical features, but what do they mean. So, what is a hypothesis, and what does it mean to be deductive? 
Consider the following:
Scientific Thought

Critical Concepts 

Hypothesis - A proposed explanation of a phenomena.
You may remember this definition from other science classes.  It is a good place to start, but for a strong hypothesis, there are characteristics you must take into account.  The following characteristic are not all inclusive, but they are important ones to begin considering.
  •  A hypothesis must be testable, and conceivably falsifiable.
    • You must be able to conceive of a way to legitimately test the hypothesis.
    • There must be conditions in which the test could reveal a negative/false result.
    • If there is no possible way to generate a negative result, then you do not have a scientific hypothesis (we did not find any evidence of ghosts, but that does not mean you don't have ghosts).
  • Succinctness - A hypothesis should have few underlying assumptions.  The more assumptions, the weaker the hypothesis (also called parsimony).

Discussion

Dr. Ignaz Semmelweis is a figure rarely discussed in general biology, but his work as one of the founders of Infection Control is important.  His work also stands as an incredible example of the hypethetico-deductive model at work:
Read the following websites/articles.  It is suggested that you read them in order.
In the discussion forum for today, describe how Dr. Semmelweis' work with puerperal fever demonstrate the scientific method at work. Look at the hypotheses he generated, and consider whether these were strong or weak?  Does the data shown in the fourth link provide support to Dr. Semmelweis' final solution? Did Dr. Semmelweis have the correct cause, or were there other discovers that ultimately explain what was happening in the First Ward?  Discuss the concept of an Agent of Change; how did Dr. Semmelweis fail as an agent of change, and consider how you would stand as an agent of change.
NOTE:  Don't answer these as individual questions.  Consider and build a response.